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Do statins really reduce risk of heart disease? By how much? Is absolute risk very low? How do absolute and relative risk compare? A general look at the science on statins and cardiovascular disease.Uploaded 06-06-22Statins: efficacy (do statins work), safety (potential side effects), funding concerns etcemotional views: everybody should be on a statin, add statins to the water supply vs statins are poisondo statins lower cardiovascular risk?clinical trials: half take a statin, half take a placebo. 22% lower risk of heart attacks, strokes etc. cardiovascular outcomesThe lower the LDL-cholesterol achieved… the lower the risk. statins lower cholesterol and ApoB lipoproteins, that's why they lower risk. but trials look at LDL-cholesterolclinical trials where cholesterol is lowered with statins: the longer the larger the benefitstatins help stabilize plaque and may reduce plaque volume but it´s a modest effectAbsolute risk is smaller, does that mean statins don’t work?Absolute risk reduction heavily determined by the risk in the control group.Relative risk reduction is more generalizable. Absolute risk reduction is more sensitive to the specific context. Absolute risk reduction tells us more about that specific experiment, Relative risk reduction gives us a general idea of what the drug can do.Connect with me:Facebook: https://www.facebook.com/DrGilCarvalho/Twitter: https://twitter.com/NutritionMadeS3Animations: Even Topland @toplandmediaReferences:https://academic.oup.com/eurheartj/article/38/32/2459/3745109#112366442https://academic.oup.com/eurheartj/article/43/4/249/6342853https://www.ahajournals.org/doi/abs/10.1161/CIRCOUTCOMES.121.008552https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.120.045851#d1e454https://www.jacc.org/doi/pdf/10.1016/j.jacc.2018.06.046https://jamanetwork.com/journals/jamainternalmedicine/article-abstract/2790055https://jamanetwork.com/journals/jama/article-abstract/199118https://www.ahajournals.org/doi/full/10.1161/01.cir.0000140261.58966.a4https://www.sciencedirect.com/science/article/abs/pii/S0021915009010053https://jamanetwork.com/journals/jama/fullarticle/2556125https://academic.oup.com/jnci/article/96/2/99/2520973https://www.jacc.org/doi/10.1016/j.jacc.2020.07.059https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4443441/https://www.jacc.org/doi/pdf/10.1016/j.jacc.2018.06.046Disclaimer: The contents of this video are for informational purposes only and are not intended to be medical advice, diagnosis, or treatment, nor to replace medical care. The information presented herein is accurate and conforms to the available scientific evidence to the best of the author's knowledge as of the time of posting. Always seek the advice of your physician or other qualified health provider with any questions regarding any medical condition. Never disregard professional medical advice or delay seeking it because of information contained in Nutrition Made Simple!.#NutritionMadeSimple #GilCarvalho0:00 Introduction0:19 My disclaimer1:34 Do statins lower risk?4:52 The effect of time9:39 Putting it all together11:01 Statins trials and industry funding12:12 Absolute vs Relative Risk18:46 Is it misleading to report relative risk?20:51 The Bottomline Learn more about your ad choices. Visit megaphone.fm/adchoices Learn more about your ad choices. Visit megaphone.fm/adchoices
