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Science Made Simple

Science Made Simple

Cold's Hidden Lifespan Switch: The BH2 Pathway | Science Made Simple

Science Made Simple · Nov 1, 2026 · 1:03

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Discover how moderately cold temperatures switch on a hidden BH2 metabolic pathway in roundworms, extending lifespan by about 15 percent. Learn how the CAT-4 enzyme in muscle makes BH2, how it travels to the gut and nerves, converts to BH4 and helps make tyrosine, and why this worm and lab-cell finding is not yet a human treatment.

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