Core Internal Medicine via following series: 5 Pearls || Clinically relevant pearls Mind the Gap || Why do we do what we do? Gray Matters || Management Reasoning Hoofbeats || Dissecting clinical reasoning At the Bedside || Explore everyday challenges
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Sep 29, 2026 · 33:31
“The triglycerides are high. Now what?” This episode breaks down a practical approach to elevated TGs, from knowing when to check ApoB or non-HDL-C to choosing lifestyle changes,…
Sep 23, 2026 · 15:20
“Too young for colon cancer.” This episode unpacks the red flags of early-onset CRC, from blood in the stool and iron deficiency anemia to persistent abdominal pain and changes…
Sep 16, 2026 · 37:37
“It didn’t work.” This episode breaks down practical treatment options (dosing options for naltrexone, acamprosate, topiramate, gabapentin) and counseling pearls to help you meet…
Sep 8, 2026 · 39:59
Have you ever lost a patient and found yourself thinking about them long after the shift ended? This episode explores the grief clinicians can carry after a patient dies,…
Aug 25, 2026 · 34:34
How to choose between RUQ ultrasound, CT, HIDA, MRCP, EUS, and ERCP based on the clinical picture? When should you move from diagnostic imaging to therapeutic ERCP, and what…
Aug 12, 2026 · 44:57
Throwback: Should you really fluid-restrict every patient with SIADH? When can IV fluids make hyponatremia better or worse? Are salt tabs actually doing enough? And what can…
Jul 28, 2026 · 32:59
Why can lower-dose combinations be more effective and better tolerated than maximizing one medication? How to troubleshoot common challenges such as amlodipine edema, gout,…
Jul 15, 2026 · 23:52
Learn from primary care docs what has been practiced and changed from the 2026 ACC/AHA Lipid Guidelines! Learn how the new CPR framework (Calculate, Personalize, Reclassify) and…
Jun 29, 2026 · 33:40
MASLD affects nearly one in three adults worldwide, yet many patients remain undiagnosed until advanced fibrosis or cirrhosis develops. So, which patients should clinicians…
Jun 17, 2026 · 25:39
What blood pressure should we target in patients on hemodialysis? Why volume control remains the foundation of treatment? How blood pressure targets differ from the general…
Jun 10, 2026 · 31:54
Why is fluid management the most important part of dialysis care? This episode explores the fundamentals of hemodialysis , why ESKD patients have unique physiology , and how…
May 27, 2026 · 29:19
Can AI manage post-op atrial fibrillation or does medicine still require human judgment? Using post-op AFib as a case study, we explore where algorithms help, where evidence…
May 18, 2026 · 27:49
We start with a gripping story of seizures and use it as a jumping-off point to unpack practical pearls for in-flight emergencies. Along the way: what’s actually in the emergency…
Apr 28, 2026 · 43:13
Can you distinguish benign eosinophilia from a sign of serious disease, and know exactly when to act at the bedside? In this high-yield episode, test your clinical reasoning as…
Apr 15, 2026 · 32:15
Is coffee helping or harming our patients’ hearts? In this Beyond Journal Club, we unpack the CRAVE trial and use it as a lens to answer a bigger question: How should clinicians…
Apr 1, 2026 · 33:30
Why can these infections be tricky? How to diagnose osteomyelitis at the bedside? Do we always need IV vs oral antibiotics? And the best for last: Simple, practical wound care…
Mar 23, 2026 · 29:19
A dialysis patient with a chronic cough: is it COPD, or are they still volume overloaded? A patient with AKI and hyperkalemia says they’re still peeing — does that rule out…
Mar 12, 2026 · 47:16
Most clinicians see dementia medications on the med rec, but many of us aren’t sure how much they actually help . In this episode we break down donepezil, memantine, and the new…
Feb 25, 2026 · 46:27
Cognitive decline is tough for all parties. What are the high-yield questions to ask? What should you add to your one-liner? When do you stop using MOCA and try to clearly…
Feb 11, 2026 · 28:14
From metformin to basal insulin to overlooked older medications, this episode reviews the T2D medication toolkit clinicians use every day. We then dive into new evidence on…
Jan 28, 2026 · 37:45
Is patient confidentiality absolute or conditional? When does protecting privacy put others at risk? Can you follow a former patient in the EHR for learning? Should you post a…
Jan 21, 2026 · 28:49
Baby alligators - those betrayals of purpose , or, death by a thousand paper cuts ! Check out our latest episode, where Dr. Eileen Barrett walks us through how to tackle baby…
Jan 7, 2026 · 38:26
Gray zones of VTE management! How to approach anticoagulation duration in unprovoked, provoked-irreversible, and provoked-reversible clots? When dose-reduced DOACs make sense for…
Dec 17, 2025 · 19:13
We hope these stories resonate with anyone who has felt pulled between professional purpose and personal life, and remind you that you’re not alone in wanting both. 🔹 Sponsor:…
Dec 10, 2025 · 21:44
Antibiotic duration for bacteremia is something most of us learned by habit, not by trial data. In this episode, we walk through the BALANCE trial and use it as a lens to revisit…
Dec 3, 2025 · 38:20
How quickly can triglycerides rise? At what threshold are patients at risk of pancreatitis or cardiovascular adverse outcomes? What do you have to rule out? How do you counsel on…
Nov 19, 2025 · 34:44
Why is venous congestion not the same as volume overload? How can looking at IVC as well as doppler on the hepatic vein, portal vein, and/or intrarenal vein help? Can venous…
Nov 5, 2025 · 36:50
SGLT-2i vs. GLP-1? vs Metformin? How do you balance the cost and coverage of first-line options like metformin, SGLT-2, and GLP-1s? How do you choose between SGLT-2 and GLP-1s…
Oct 22, 2025 · 30:34
What really works when treating HRS? Vasoconstrictors like terlipressin vs. norepinephrine vs. midodrine: how do we decide which to use? Do you give albumin? When do you give…
Oct 15, 2025 · 36:11
HRS-AKI vs. other causes of AKI in cirrhosis: What do serum or urine sodium clues, albumin challenges, and shifting diagnostic criteria actually reveal about getting the…
Oct 1, 2025 · 30:50
Who’s really at risk for fractures, and how should we be treating them? Most fragility fractures occur in patients without osteoporosis. Should we rethink who gets treated? And…
Sep 22, 2025 · 35:35
Medications for orthostatic hypotension! When to initiate treatment, how to use them safely, and what to do when new issues arise during treatment. How do those change if someone…
Sep 11, 2025 · 37:20
Learn specific, practical ways to counsel patients on non-pharmacologic interventions. What is our goal with OH treatment? Is it the blood pressure number that matters? How do we…
Aug 25, 2025 · 37:03
Next time you’re squinting at a chest tube, feel confident you know exactly what to look for and why. Hear it explained in a way that really sticks! 🔹 Sponsor : Oakstone CME’s…
Aug 13, 2025 · 42:21
How do you work up neutropenia? When is neutropenia benign? When do neutrophils recover? How can you diagnose neutropenic fever in the first 15 minutes and start antibiotics in…
Jul 28, 2025 · 10:44
Have a good laugh and reflect deeply with these three stories that hit the feels in different ways. If you'd love to hear more stories from Dr. Maria Rosasco, check out some of…
Jul 21, 2025 · 33:11
What went wrong? What were the reasoning or contextual missteps that led us astray? 🔹 Sponsor : NEJM Fellowship Program, click here to learn more and/or apply ! Due Aug 1, 2025…
Jul 9, 2025 · 36:15
Imaging Pearls | (01:12) Deciding on Thoracentesis | (04:00) Light’s Criteria and Pseudoexudates | (07:00) Pleural Fluid Studies: pH and Cell Differential | (16:56) Diagnosing…
Jul 2, 2025 · 15:58
Listen for some good laughs and relatable stories! In this episode, we share raw and real stories from July — from rapid responses to unexpected kindness — and reflect on the…
Jun 25, 2025 · 26:41
How much do beta blockers help after a heart attack, even when the heart’s pumping well? In this episode, we revisit the origins of beta blockers in post-MI care , examine how…
Jun 11, 2025 · 45:02
🔹 What is invasive fungal disease, and who is most at risk for developing invasive fungal disease? (~ 02:46) 🔹 What are the main classes of fungi? (~11:35) 🔹 What are the pros…
Jun 2, 2025 · 33:34
🔹What are clinically relevant limitations of an A1c vs. a CGM (1:40) 🔹What do the different parts of the ambulatory glucose profile tell you? (09:59) 🔹What are common…
May 14, 2025 · 43:53
🔹When is an U/S vs. CT vs. MRI helpful before consulting Interventional Radiology? 🔹What factors go into an IR pre-op evaluation? 🔹 When do drains go in, and when do they come…
Apr 30, 2025 · 39:43
🔹 High-yield reversible causes of constipation? (02:26) 🔹 Which type of fiber is more helpful? And is more hydration really better? And bulk-forming laxatives (9:03) 🔹 Osmotic…
Apr 16, 2025 · 27:44
How good are we at preventing HIV? How do efficacy and effectiveness differ? We journey from oral pre-exposure prophylaxis (PrEP) to long-acting injectables , and then to the…
Apr 2, 2025 · 43:20
What does Lipoprotein(a) tell us that a standard lipid panel doesn’t? Should we be testing everyone for it? Dive into the genetics, clinical implications, and evolving management…
Mar 19, 2025 · 44:49
A new way to think of clots beyond provoked vs. unprovoked: Learn all about how important it is to think about reversibility! What patient states affect the inherited…
Mar 5, 2025 · 33:36
What is the impact of microplastics on human health? How can we use observational data to support the argument that microplastics may lead to poor health outcomes? Join us as we…
Feb 27, 2025 · 20:51
What is the last sense to go? How can music create connection, ease anxiety, and help process emotions at the end of life? Join Dr. Jafar Al-Mondhiry, Dr. Harry Han, and music…
Feb 5, 2025 · 34:59
Incidental fibrosis on CT —what now? What does prone imaging tell you? Is it fibrosis, aspiration, or atelectasis? And once you diagnose ILD, does the “alphabet soup” really…
Jan 22, 2025 · 52:23
SPEP vs. UPEP? What does it tell you and not tell you? What is the role for immunofixation and free light chains in diagnosis? Learn about paraneoplastic antibodies with MGCS and…
Jan 8, 2025 · 42:39
How do you differentiate immune checkpoint inhibitor-related adverse events aka IrAEs from other conditions like infection? Join as we go through pneumonitis, colitis, dermatitis…
Dec 30, 2024 · 11:29
YouTube Videos Anion Gap Metabolic Acidosis: https://youtu.be/oE0lygmMANM Inhaler Delivery Systems: https://youtu.be/yYPdjClm9Bg Iron Deficiency in Pregnancy…
Dec 11, 2024 · 32:16
What’s the evidence been for the use of PPIs in mechanically ventilated patients? What do more recent studies reveal about PPIs and possible harmful side effects of aspiration…
Nov 27, 2024 · 44:09
Why are we missing peripheral arterial disease (PAD)? How is it diagnosed using the Ankle-Brachial Index (ABI)? What treatments improve symptoms and reduce cardiovascular risks?…
Nov 14, 2024 · 29:31
How is TPN and PPN similar and how is it different? When should each be used? How does bacterial overgrowth lead to complications? Does TPN cause diarrhea? Transcript and Show…
Oct 30, 2024 · 32:47
Limitations to urine drug screening (UDS) in primary care? What are common false positives and false negatives with the urine drug screen test? Transcript and Show notes Behind…
Oct 16, 2024 · 38:22
What if a patient can't afford hospice? Which medications do you deprescribe when on hospice? What happens when patients who are on hospice return to the hospital or ED? Sponsor…
Oct 2, 2024 · 29:34
Can the MINT trial change how we treat anemia in acute MI? The largest trial of its kind compared liberal vs. restrictive transfusion strategies in patients with myocardial…
Sep 18, 2024 · 25:44
Strategies to address moral distress and moral injury — hear from the experts on their work on the topic! Transcript and Show notes Subscribe to Core IM’s YouTube Channel for…
Sep 11, 2024 · 27:04
What is moral residue vs. moral injury vs moral distress? How do these concepts impact us as clinicians? Sponsor : Whether you're looking to open your own practice or buy into a…
Aug 28, 2024 · 28:40
Listen to 3 cardiorenal cases that highlight that “without flow it really doesn't matter what you're doing with the diuretic!” Sponsor : Freed is an AI scribe that listens and…
Aug 7, 2024 · 31:08
Signouts! How can we do them better? Hear these memorable stories & ask yourself these FIVE questions when getting your handoff ready for the covering team. Sponsor : Glass…
Jul 24, 2024 · 39:17
Sponsor : Freed is an AI scribe that listens and writes your note in < 30 seconds. Freed learns your style over time and is HIPAA compliant! Use the code CORE50 to get 50% off…
Jul 3, 2024 · 21:35
Dive into 4 microskills from the book “Microskills: Small Actions, Big Impact” that offer tangible tools for navigating the professional world with grace and intention. Book by…
Jun 19, 2024 · 29:30
Does colonoscopy prevent colon cancer, and does it save lives? There has never been a randomized controlled trial on screening colonoscopies before NordICC trial, even though it…
Jun 5, 2024 · 39:46
Sponsor : Freed is an AI scribe that listens and writes your note in < 30 seconds. Freed learns your style over time and is HIPAA compliant! Use the code CORE50 to get 50% off…
May 22, 2024 · 30:44
Sponsor: At Panacea Financial, you don't need co-signers for personal loans and have reduced payments during training! Behind the Scenes YouTube Interview Transcript and Show…
May 13, 2024 · 39:42
Sponsor : Freed is an AI scribe that listens and writes your note in < 30 seconds. Freed learns your style over time and is HIPAA compliant! Use the code CORE50 to get 50% off…
Apr 24, 2024 · 40:08
What are the benefits of early rhythm control versus rate control alone? When is electrical cardioversion used and what information can it tell us? What side effects for…
Apr 10, 2024 · 33:46
Should your patients be reaching for albuterol when their asthma flares up? Some of us may have been treating asthma exacerbations incorrectly for many years… What is the right…
Mar 27, 2024 · 39:42
How do you choose btw PO vs. IV iron? What is the best counseling for oral iron formulations? How do you choose between different IV iron formulations? Should you use the Ganzoni…
Mar 13, 2024 · 39:15
What do the different iron labs mean?! How to interpret iron labs in the setting of inflammation? How to take a good menstrual history? Sponsor : Freed is an AI scribe that…
Feb 28, 2024 · 42:51
Uncover many blind spots on tube feeds! Sponsor: At Panacea Financial, every single customer gets their OWN 24/7 primary care banker who actually knows you! Behind the Scenes…
Feb 14, 2024 · 38:35
How do you manage GDMT in a frail older adult? When is a guardian needed and what is the process for obtaining guardianship? Sponsor: Echonous, the maker of Kosmos , is…
Jan 31, 2024 · 23:28
How do you counsel patients eligible for the RSV vaccines? What do the results of the RENOIR and AReSVi trials tell us and how do they compare? How should we interpret vaccine…
Jan 17, 2024 · 37:57
When you see a low mag or a low phos, what are you thinking about? And do PPIs effect magnesium absorption? How much sodium and potassium are found in a typical oral phosphorus…
Dec 27, 2023 · 38:37
Sharpen your de-escalation skills! Sponsor: GlassHealth | Get unlimited A.I queries for 1 month with promo code: COREIM ! Timestamps: 02:26 Difficult Patients 10:25 Mediation…
Dec 6, 2023 · 22:07
In community-acquired pneumonia, can steroids improve mortality? Past studies of steroids in CAP have been conflicting, with some showing a mortality benefit and others showing…
Nov 29, 2023 · 24:46
Syncope history, PPM/ICD prior to MRI or surgery, anticoagulation for pacemaker or ICD procedures and new cardiac devices and how they may look different on EKG or chest x-ray!…
Nov 8, 2023 · 26:27
Is Cr or Cystatin C better to assess eGFR? What are pros & cons of each? Does eGFR tell the full picture of kidney function? What may cause false positive albuminuria? Sponsor :…
Oct 25, 2023 · 32:05
Check out the original interview on Youtube : Essentials on Genetic Counselor | Lynch Syndrome Who should be referred for genetic counseling? How can we set our our patients and…
Oct 18, 2023 · 34:03
See some of the original interviews on Youtube ! What is the evidence behind K+ repletion? What is a framework to think through for hypokalemia? What are the different repletion…
Oct 4, 2023 · 21:59
What is the difference between semaglutide (ozempic) and tirzepatide (mounjaro) in outcomes and mechanism? How did we find out diabetes medications can help with weight loss?…
Sep 20, 2023 · 36:50
With progressing CKD & HFrEF, what GDMT medications can you start, continue or stop? What does the data on hydralazine/isosorbide tell us and what does it NOT tell us? What are…
Sep 6, 2023 · 30:24
What does medical education research say about improving diagnostic errors? What habits help in getting to diagnostic excellence? Timestamps 01:00 System 1 vs. System 2 07:46…
Aug 16, 2023 · 44:36
What are side effects of tacrolimus and mycophenolate? And what are common medication interactions? What causes of acute kidney injury are unique to renal transplant recipients…
Aug 2, 2023 · 17:48
In patients with heart failure with low ejection fraction and chronic coronary disease without unstable symptoms, does stenting open blocked coronary arteries extend life or…
Jul 19, 2023 · 22:31
Laugh and be humbled along some of Dr. Maria Rosasco's most memorable July stories ! Listen to the original July Stories: https://bit.ly/3Y4n8jG Behind The Scenes videos on…
Jul 6, 2023 · 14:04
BONUS on Cosyntropin stimulation tests! What exactly is it? How do you interpret them? What is the difference between adrenal insufficiency and steroid withdrawal syndrome? Use…
Jun 28, 2023 · 41:23
How do you choose between the different steroids? At what dose and duration do you get concerned about worrisome complications? What types of prophylaxis should be started in…
Jun 14, 2023 · 31:56
In cirrhosis, what actually contributes to the bleeding vs. clotting risk? Does the INR capture it? What is in FFP? Do you have to give FFP prior to a paracentesis and a…
May 31, 2023 · 28:20
How long can fatigue last for after radiation? Are all patient post radiation immunocompromised? What are the potential acute and long-term side effects after lung, breast,…
May 24, 2023 · 26:00
What are the different types of radiation? What should we and shouldn’t we put in our one-liners? What makes palliative radiation different from curative radiation? And when to…
May 15, 2023 · 23:21
What did you have to "unlearn" in your learning journey? How do you organize your time? Organize how you keep up with medical evidence? What is your calendar management system?…
Apr 26, 2023 · 21:21
What does the HbA1c really measure? What are its limitations? How does fructosamine and glycated albumin work? What will falsely elevate or decrease it? What are the benefits of…
Apr 12, 2023 · 47:31
When do you have a device interrogated? Do you know what kind of device your patient has? Do you know how to manage patients with a device who develop bacteremia? How do you…
Mar 29, 2023 · 46:03
How does transplant compare to dialysis? Who is a good candidate for a kidney transplant? How long do patients have to wait for a deceased donor kidney transplant? What can…
Mar 8, 2023 · 42:58
What is your approach to trach complications? What do all the words in the one liner of a trach patient mean? What are best practices for airway clearance? When is a patient…
Mar 2, 2023 · 18:37
Why are safety net hospitals barely surviving? What makes a hospital a safety net hospital? How essential are safety net hospitals in caring for low income Americans? How do we…
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