Episode 377: Methylene Blue for Mitochondria & Performance: Benefits, Dosing & Risks with Dr. Scott Sherr — Flex Diet Podcast

In this episode of the Flex Diet Podcast, I sit down with Dr. Scott Sherr to take a deep dive into methylene blue, mitochondrial function, and where the truth lies between online hype and fear. We talk through how methylene blue acts as a redox cycler in the mitochondria, how dosing differs for mitochondrial support versus antimicrobial use, and why high doses or poorly labeled liquid droppers can cause problems.

Dr. Sherr also shares how he’s used methylene blue with athletes for recovery and endurance, including timing, half-life, and practical ranges he sees most often. We cover how mitochondrial health connects to energy, mood, focus, stress physiology, and recovery, plus resources from Transcriptions and the Health Optimization Medicine and Practice (HOMe/HOPe) framework.

Sponsors:

TROScriptions TX: https://troscriptions.com/?rfsn=9054607.066ddde&utm_source=refersion&utm_medium=affiliate&utm_campaign=9054607.066ddde
- CODE: DRMIKE
Daily Fitness Insider Newsletter: https://flex-diet.kit.com/bfa1510fa8

Coming up:

ISSN 2026: https://www.sportsnutritionsociety.org/

Available now:

Grab a copy of the Triphasic Training II book I co-wrote with Cal Deitz here.

Episode Chapters:

03:11 Why Methylene Blue Now
04:29 Scott Cher Origin Story
05:05 Health Optimization Framework
07:08 Transcriptions and Safe Sourcing
08:46 Natural vs Synthetic Debate
11:49 How Methylene Blue Works
17:42 Who Benefits Most
22:13 Athletic Performance and Recovery
29:41 Dosing Timing and MAOI Effects
32:13 Mitochondria and Fertility
32:28 Energy Anxiety and Brain Fog
33:13 Depression Beyond Serotonin
35:30 Stress Pathways and Cell Danger
37:00 ADHD or Sympathetic Overdrive
38:50 Recovery Metrics and Downregulation
42:21 GABA Support and BBB Clues
47:50 Building Mitochondrial Capacity First
51:35 Methylene Blue Dosing Guide
57:54 Where to Learn More
01:00:24 Podcast Wrap and Disclaimer

Flex Diet Podcasts you may enjoy:

Episode 344: Metabolic Adaptations, Lactate, and Training Smarter with Dr. Phil Batterson
- YouTube: https://www.youtube.com/watch?v=PPZyO1nxSPA
Episode 320: Unlocking Mitochondrial Secrets with Dr. Hemal Patel
- YouTube: https://www.youtube.com/watch?v=lQGXtZjJtQw

Connect with Dr Sherr:

Instagram: https://www.instagram.com/drscottsherr/
Website: https://drscottsherr.com/
YouTube: https://www.youtube.com/@drscottsherr

Get In Touch with Dr Mike:

Get the Daily Fitness Insider newsletter (free): https://www.miketnelson.com/newsletter