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Come on government, change the out dated guidelines. John's text books, free downloads,Uploaded 29-05-22http://159.69.48.3/Vitamin D regulates a wide array of genes involved in inflammation and immunity, inconsistently associated with reduced risk of several autoimmune diseases in observational studiesActive form of vitamin D regulates genes, inflammation, acquired and innate immune responsesDietary marine derived long chain omega 3 fatty acids decrease systemic inflammation in some autoimmune diseasesEvidence is needed on whether omega 3 fatty acids lower the risk of developing autoimmune disease Vitamin D and marine omega 3 fatty acid supplementation and incident autoimmune disease: VITAL randomized controlled trialhttps://www.bmj.com/content/376/bmj-2021-066452To investigate whether vitamin D and marine derived long chain omega 3 fatty acids reduce autoimmune disease risk. Vitamin D and omega 3 trial (VITAL), a nationwide (US), randomized, double blind, placebo controlled trialN = 25, 871consisting of,12, 786 men ≥5013, 085 women ≥5518,046 non- Hispanic white5,106 black2,152 as other racial and ethnic groupsMean age was 67.1INTERVENTIONS Vitamin D (2000 IU/day) or placeboOmega 3 fatty acids (1000 mg/day) or placeboParticipants self-reported all incident autoimmune diseases from baseline to a median of 5.3 years,these diseases were confirmed by medical record reviewIn the vitamin D armTreatment group123 developed an autoimmune diseasePlacebo group155 developed an autoimmune diseaseHazard ratio 0.78P = 0.05In the omega 3 fatty acids armTreatment group130 developed an autoimmune diseasePlacebo group148 developed an autoimmune diseaseP=0.19CONCLUSIONS Vitamin D supplementation for five yearswith or without omega 3 fatty acids, reduced autoimmune disease by 22%Omega 3 fatty acid supplementationwith or without vitamin D,reduced the autoimmune disease rate by 15%(not statistically significant)The clinical importance of this trial is high because these are well tolerated, non-toxic supplements, and other effective treatments to reduce the incidence of autoimmune diseases are lacking Autoimmune diseasesRheumatoid arthritisPolymyalgia rheumaticaHashimoto’s thyroiditis, too little thyroid hormone)PsoriasisType 1 diabetes mellitusMultiple sclerosisLupusInflammatory bowel disease (Crohn’s Ulcerative colitis)Addison’s (too little of cortisol)Grave’s (too much thyroid hormone), Myasthenia gravisPernicious anemiaAutoimmune vasculitisCeliac disease (gluten protein from grains)Inflammatory autoimmune response to self-tissuesThird leading cause of morbidity in the industrialized worldChronic conditionsIncreasing prevalence with ageLack of effective treatmentsMore about the VITAL RCThttps://clinicaltrials.gov/ct2/show/NCT01169259VITamin D and OmegA-3 TriaL (VITAL) A randomized clinical trial, US basedN = 25,871InvestigatingDaily dietary supplements of vitamin D3 (2000 IU),or omega-3 fatty acids (Omacor® fish oil, 1 gram),reduces the risk of developing,cancerheart diseasestroke,in people with no specific history 5-year intervention phase (study pill-taking, median 5.3 years) has endedpost-intervention observational follow-up, ongoing Learn more about your ad choices. Visit megaphone.fm/adchoices Learn more about your ad choices. Visit megaphone.fm/adchoices
