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The association between acute transverse myelitis and COVID-19 vaccination in KoreaUploaded 05-04-25https://onlinelibrary.wiley.com/doi/10.1111/ene.70020Acute transverse myelitis (ATM) has been reported as a potential association between COVID-19 vaccination. https://pubmed.ncbi.nlm.nih.gov/38350768/Results368 ATM cases diagnosed after first COVID-19 vaccination during the study period (159 ATM patients were included).Among them, 82 (51.6%) were maleThe incidence rate ratio (IRR) was 2.41,for the ATM risk within 1–42 days after COVID-19 vaccination. The IRR (Incidence Rate Ratio)3.31 for ChAdOx1-S (AZ)1.99 for BNT162b2 (Pfizer)2.57 for mRNA-1273 (Moderna)3.33 for Ad26.COV2.S (Janssen)MethodsA self-controlled case series studyhttps://www.bmj.com/content/354/bmj.i4515Large database that combines the COVID-19 vaccine registry and the national claims database. The COVID-19 vaccinationData, information on individuals aged 18 + who received COVID-19 vaccination from February 26, 2021, to August 31, 2022. Patients who developed acute transverse myelitisThe claims database covered the entire Korean populationPatients who develop ATM within 1–42 days following COVID-19 vaccinationThe observation period was 270 days after the first dose of the COVID-19 vaccine. ConclusionThese findings indicated an increased risk of ATM following COVID-19 vaccination within 42 days. An association with the risk of ATM was found both for viral vector and mRNA vaccines.Acute transverse myelitis (ATM)A rare neurological disorderInflammation of the spinal cordCan lead to sensory and motor deficits, paralysis, severe disability, autonomic lossThe causes of ATM are uncertain; however, it is known to be associated with autoimmunity triggered by various environmental factors, including vaccination.DISCUSSIONThis nationwide population-based SCCS study identified a significant increase in the incidence of ATM within 1–42 days following COVID-19 vaccination. Our findings contribute to the ongoing debate on the safety profiles of COVID-19 vaccines by providing evidence of potential neurological complications.An emerging patternNeurological complications after first dose of COVID-19 vaccines and SARS-CoV-2 infectionhttps://onlinelibrary.wiley.com/servlet/linkout?suffix=null&dbid=8&doi=10.1111%2Fene.70020&key=34697502&getFTLinkType=true&doiForPubOfPage=10.1111%2Fene.70020&refDoi=10.1038%2Fs41591-021-01556-7&linkType=PMID&linkSource=FULL_TEXT&linkLocation=ReferenceEmerging reports of rare neurological complications associated with COVID-19 infection and vaccinations are leading to regulatory, clinical and public health concerns. Acute Transverse Myelitis after COVID-19 Vaccinationhttps://pubmed.ncbi.nlm.nih.gov/34684047/#full-view-affiliation-1The adverse effects of the COVID-19 vaccine have been discovered as the rapid application of the vaccines continues. Neurological complications such as transverse myelitis raise concerns as cases were observed in clinical trials.Overview of Transverse Myelitis after COVID-19 vaccination https://www.lareb.nl/Knowledge/FilePreview?id=42797&p=33550Until January 16th 2023, The Netherlands Pharmacovigilance Centre received 48 reports of TM following COVID-19 vaccination. Neurological side effects of SARS-CoV-2 vaccinationshttps://onlinelibrary.wiley.com/servlet/linkout?suffix=null&dbid=8&doi=10.1111%2Fene.70020&key=34750810&getFTLinkType=true&doiForPubOfPage=10.1111%2Fene.70020&refDoi=10.1111%2Fane.13550&linkType=PMID&linkSource=FULL_TEXT&linkLocation=ReferenceThe most frequent neurological side effects of SARS-CoV-2 vaccines are headache, Guillain-Barre syndrome (GBS), venous sinus thrombosis (VST), and transverse myelitis. A systematic review of cases of CNS demyelination following COVID-19 vaccinationhttps://onlinelibrary.wiley.com Learn more about your ad choices. Visit megaphone.fm/adchoices
