Pearls and Prep · Jul 30, 2026 · 33:25
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How I Choose Antipsychotics in Real Clinical Practice: 4 Pearls That Will Transform Your Bipolar Prescribing
How do experienced psychiatric providers actually choose between Seroquel, Abilify, Latuda, Vraylar, Risperdal, Zyprexa, and Geodon? In this episode, I share the exact clinical framework I use every day when prescribing second-generation antipsychotics (SGAs) for bipolar disorder. Rather than memorizing medication lists, you'll learn four practical prescribing pearls that simplify complex decisions and help you match the right medication to the right patient.
We'll cover acute mania versus bipolar depression, maintenance therapy, medication receptor profiles, metabolic considerations, weight gain, sedation, akathisia, prolactin elevation, movement disorders, and how patient-specific goals should influence every prescribing decision. You'll also learn why treating the episode in front of you isn't enough—and why thinking one step ahead can dramatically improve long-term outcomes for your patients.
Whether you're a PMHNP student, psychiatry resident, physician assistant, psychiatric nurse practitioner, or practicing clinician, this episode will help you prescribe with greater confidence, stronger clinical reasoning, and a deeper understanding of why one antipsychotic may be a much better choice than another.
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How I Choose Antipsychotics in Real Clinical Practice: 4 Pearls That Will Transform Your Bipolar Prescribing
Pearls and Prep
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