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In today's episode, Dr. Jeremy London, board-certified cardiovascular surgeon, breaks down the most common cholesterol question he gets: how do you actually lower your ApoB? He explains why ApoB predicts cardiovascular risk better than LDL-C, why insulin sensitivity is the through line connecting sugar, saturated fat, fiber, muscle, and body weight, and what to do when you've done everything right and your numbers still won't budge.
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Timestamps:
00:00:00 The #1 Cholesterol Question I Get Asked 00:01:00 Why Nobody Knew What ApoB Was 10 Years Ago 00:01:40 LDL-C vs. ApoB: The Truck Analogy 00:03:20 What Is an "Optimal" ApoB? (90 / 80 / 70) 00:05:00 Why Your Doctor Isn't Testing For This 00:06:20 The Two Foundational Buckets 00:07:20 Diet #1: Sugar, Starch & the Insulin Connection 00:11:20 Diet #2: Saturated Fat and the Substitution Trap 00:13:20 Diet #3: Fiber — Not Sexy, But It Works 00:16:20 Is Dietary Cholesterol Actually the Problem? 00:19:20 Exercise #1: Muscle Is Your Biggest Glucose Sink 00:21:40 Exercise #2: Weight Loss & Visceral Fat 00:24:40 What If You Do Everything and Nothing Changes? 00:26:40 Medications Are NOT a Failure 00:29:00 Statins: The Most Demonized Drug in Medicine 00:32:40 Ezetimibe 00:34:00 PCSK9 Inhibitors & the Genetic Evidence 00:36:40 Bempedoic Acid 00:38:00 Why Medication Alone Is Never Enough 00:39:20 Pulling Every Lever 00:40:40 Thank You For Listening!
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