Genetic Pathways to Longevity: Harnessing Polygenic Risk Scores for Personalized Age-less Interventions
The Catalyst Clinic: The Science of Age-less Living · Sep 6, 2025 · 30:51
The Catalyst Clinic: The Science of Age-less Living
The Catalyst Clinic: The Science of Age-less Living · Sep 6, 2025 · 30:51
Listen in the Podli app 🎧
Follow your favourite podcasts, listen offline and in the car with CarPlay and Android Auto, and always pick up where you left off. Free to try.
Dive into polygenic risk scores (PRS) and discover how your genetic blueprint can inform personalized longevity strategies. Dr. Ethan Hausman-Marquis breaks down genome sequencing, five major genetic pathways to aging (DNA repair, metabolism, inflammation, mitochondria, neurodegeneration), and real-world clinical applications from The Catalyst Clinic.
Learn how PRS can shift prevention from one-size-fits-all to truly individualized interventions—while understanding limits like population bias and probabilistic risk. Perfect for longevity science fans curious about precision medicine, NAD+, peptides, and building cognitive and mitochondrial resilience. If this episode helped you, please like and share with someone interested in age-less living. #PolygenicRiskScore #Longevity #PrecisionMedicine #AntiAging #Genomics
OUTLINE:
00:00:00 Title and Introduction
00:02:35 Genes Aren't Destiny
00:06:19 What Is a Polygenic Risk Score?
00:10:28 Two Patients Example
00:13:17 Five Major Pathways
00:20:58 Limitations and Caveats
00:25:30 Clinical Application
00:27:56 Emotional Impact
00:29:58 Closing Reflection
Episodes: The Catalyst Clinic: The Science of Age-less Living
