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Everyday Wellness: Midlife Hormones, Menopause, and Science for Women 35+

Everyday Wellness: Midlife Hormones, Menopause, and Science for Women 35+

Ep. 599 “Why You’re Getting More Infections in Midlife – The Microbiome Shift No One Talks About | Menopause, Perimenopause and Immune Health

Everyday Wellness: Midlife Hormones, Menopause, and Science for Women 35+ · May 28, 2026 · 21:25

0:0021:25

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Welcome to the latest Midlife Minute.

I’ve been getting many questions about viruses, bacterial vaginosis, and recurrent infections. So, today, I’m stepping a little outside our usual topics to explore how changes in the gut microbiome can directly influence the vaginal microbiome.

Join me as I clarify what actually happens in the body during perimenopause and menopause, and explain why those shifts matter more than most women realize.

IN THIS EPISODE, YOU WILL LEARN:



Three changes that occur simultaneously during perimenopause and menopause, and how those changes increase our susceptibility to viruses like herpes.




Why declining estrogen weakens the vaginal microbiome




How gut microbiome changes in midlife affect the ability to recycle estrogen via the estrobolome




Why the gut barrier becomes less stable and more permeable during perimenopause and menopause, and how that can trigger immune responses and low-grade inflammation




How hormonal fluctuations can trigger viral outbreaks and increase the likelihood of shingles




What research shows about hormone replacement therapy and lower rates and recurrence of severe herpes simplex infections




Why bacterial vaginosis is becoming more common in midlife




How to balance and support the gut and vaginal microbiome in midlife




Connect with Cynthia Thurlow  



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Check out Cynthia’s website.




Submit your questions to support@cynthiathurlow.com




Join other like-minded women in a supportive, nurturing community: The Midlife Pause/Cynthia Thurlow. 




Cynthia’s Menopause Gut Book is on presale now!




Cynthia’s Intermittent Fasting Transformation Book




The Midlife Pause Supplement Line




Links:

1. Menopausal shift on women’s health and microbial niches

2. The Effect of Menopause on the Innate Anti-Viral Activity of Cervicovaginal Lavage

https://pmc.ncbi.nlm.nih.gov/articles/PMC4519412/ 

3. Spotlight on the Gut Microbiome in Menopause: Current Insights

4. Shingles and Menopause: Is There a Connection?

5. The Impact of Hormonal Replacement Therapy on Herpes Simplex Infection and Gingival Health in Post-Menopausal Women 

6. The Menopause Transition, Vaginal Health, and Your Vaginal Microbiome

7. Probiotics in the Prevention and Treatment of Postmenopausal Vaginal Infections: Review Article

8. G. vaginalis increases HSV-2 infection by decreasing vaginal barrier integrity and increasing inflammation in vivo

9. Association between Acquisition of Herpes Simplex Virus Type 2 in Women and Bacterial Vaginosis 

10. Recalcitrance of bacterial vaginosis among HSV-2 seropositive women

  

Episodes: Everyday Wellness: Midlife Hormones, Menopause, and Science for Women 35+

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