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Today, I’m honored to connect with Dr. Salome Masghati, founder of Precision Gynecology, which provides the unhurried, root-cause-oriented care often missing in a system where women are rushed through short appointments, focusing on bioidentical hormone therapy, perimenopause, and menopause. Dr. Masghati has extensive surgical training and specializes in longevity medicine.
In today’s discussion, we explore the ovary as a signaling hub, not just a reproductive timer, and Dr. Masghati shares her views on hormone replacement therapy timing, intrinsic and infradian rhythm, ovarian function, and the differentiators between PCOS and PMOS in midlife women. We also cover oral versus transdermal estradiol therapy, FSH testing as an independent risk factor for bone and heart health, hysterectomies, ferritin and iron deficiency, coronary vasospasm, elevated Lp(a), estradiol and thyroid therapy, peptides, regenerative and esthetic offerings. Dr. Masghati also offers her personal perspective on what influences orgasms.
Stay tuned for today’s invaluable conversation with Dr. Salome Masghati on optimizing women’s health in midlife and beyond.
IN THIS EPISODE, YOU WILL LEARN:
How a hysterectomy, partial hysterectomy, and other surgical interventions can impact ovarian function
Dr. Masghati shares her approach to hormone replacement therapy for women going through premature or early menopause
How elevated androgen levels, insulin resistance, and inflammation can affect the response to hormone replacement therapy in women with PCOS/PMOS
Why Dr. Masghati generally prefers transdermal rather than oral estradiol
How optimizing hormone levels can improve libido when women’s hormones change
Women may have low ferritin even when their serum iron looks good.
Declining estrogen may contribute to coronary vasospasm in women.
What women should know about regenerative therapies using PRP
Why the source of peptides matters, and why Dr. Masghati specifically advises against using research peptides
Bio:
Dr. Salome Masghati is a board-certified gynecologic surgeon who now focuses on hormonal wellbeing, functional medicine, and disease prevention. She specializes in women’s health conditions including perimenopause, PCOS, endometriosis, gut health, and metabolic dysfunction, using a root-cause and physiologic approach to help women restore balance and optimize their health.
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