Extend with Darshan Shah, MD is a podcast dedicated to cutting-edge science, research, tools, and protocols designed to help you extend your healthspan. Starting my medical journey at 16 and becoming one of the youngest doctors in the country, studying and training at the Mayo Clinic, Harvard Business School, Singularity University and other prestigious institutions, becoming a board certified surgeon and accumulating over two decades of practice, I have discovered that a mere 20% of health knowledge yields 80% of the results. That's why this podcast is all about cutting through the noise on how to turn back the aging clock. I interview...
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Sep 29, 2026 · 1:10:41
What if we stopped guessing about the brain and started measuring it? In today's episode, my guest is Sat Randhawa of One-Hype Wellness, where he and his team are focused on…
Sep 24, 2026 · 52:58
Most people know they should eat more fiber. But what we're learning about fiber, gut health, and the microbiome goes far beyond digestion . Your gut contains trillions of…
Sep 22, 2026 · 1:23:25
What if the biggest mistake you're making with your health isn't what you're eating - but the way you're thinking about nutrition in the first place? In this episode, I'm joined…
Sep 17, 2026 · 1:09:59
What if the fatigue, brain fog, low energy, and other symptoms we associate with getting older actually begin much deeper—at the level of our cells? I've followed Dr. Will Cole's…
Sep 15, 2026 · 1:10:25
What if medicine could do more than manage disease—and actually help the body repair itself? Regenerative medicine is moving quickly, but the world of stem cells, PRP, exosomes,…
Sep 10, 2026 · 58:59
What if your eyesight is 20/20—but your vision still isn't working the way it should? Dr. Bryce Appelbaum specializes in functional vision and the connection between the eyes and…
Sep 8, 2026 · 57:56
What happens when optimizing your health starts taking over your life? Ben Greenfield has spent decades at the forefront of biohacking, fitness, human performance, and…
Sep 3, 2026 · 54:09
What if the fatigue, brain fog, inflammation , or unexplained symptoms you're experiencing aren't starting inside your body—but in the environment around you? Dr. Jill Carnahan…
Sep 1, 2026 · 1:20:27
Walk into any supplement aisle—or scroll through social media—and you'll find thousands of products promising better energy, performance, brain health, and longevity. But which…
Aug 27, 2026 · 58:33
What if the reason you're still sick isn't because there's no answer—but because no one has looked deeply enough for the root cause? My guest, Dr. Mark Hyman , is one of the…
Aug 25, 2026 · 50:37
What if ADHD isn't just an attention problem—but also a problem of emotional regulation? My guest, Dr. Sasha Hamdani, is a board-certified psychiatrist, ADHD specialist, author,…
Aug 20, 2026 · 1:09:12
What if your risk of Alzheimer's isn't predetermined by your genes—but influenced by the metabolic health of your brain? My guest, Dr. David Perlmutter , is a board-certified…
Aug 18, 2026 · 1:11:52
What if the biggest mistake we're making with gut health is treating the microbiome like a list of bacteria instead of a living ecosystem? Your gut is home to trillions of…
Aug 13, 2026 · 58:00
What if one of the most important markers for your heart, brain, and longevity is something most people have never measured? AND roughly 90% of Americans aren't in the optimal…
Aug 11, 2026 · 35:34
What if aging isn't something you simply accept - but something you can measure, predict, and even reverse? Most of us are told our lab work is "normal," yet chronic disease…
Aug 6, 2026 · 1:06:57
We're living in a culture that celebrates being busy. More coffee. More hours. More hustle. But what if those things are actually making you less productive? The truth is, many…
Aug 4, 2026 · 59:28
Hashimotos isn't just a thyroid disease-it may actually begin in the gut. If you've been told your thyroid labs are "normal" but you still struggle with fatigue, bloating,…
Jul 30, 2026 · 1:09:24
A leader's unresolved pain rarely stays contained within that leader. It can show up as control, aggression, emotional distance, relentless pressure, or a workplace where people…
Jul 28, 2026 · 52:30
I have operated on patients whose bodies had been sending them warning signals for years before a crisis ever put them in front of me. Stress alone causes or worsens more than 80…
Jul 23, 2026 · 1:06:06
Millions of people wear a CPAP machine every night, the standard breathing device prescribed for sleep apnea. They trust the number on the screen to tell them their sleep apnea…
Jul 21, 2026 · 53:56
For most people, an ADHD diagnosis, an anxiety diagnosis, or a depression diagnosis is made entirely from a symptom checklist. No one looks at the brain producing those symptoms.…
Jul 16, 2026 · 57:41
A lot of people do not need to be convinced that the stairs are better than the escalator, walking is better than sitting all day, and reaching for the phone every quiet second…
Jul 14, 2026 · 49:40
For many women, the hormone conversation starts only when something becomes hard to ignore. Painful periods. Irregular cycles. Acne. Hair loss. Fertility struggles. Perimenopause…
Jul 9, 2026 · 57:14
When labs look normal, it is easy to assume the body is fine or that the biggest risks have been ruled out. Dr. John Kim's story challenges that belief. At 33, after a normal…
Jul 7, 2026 · 46:00
Most people assume that once they leave a mold-exposed building, their body should recover. But I see this all the time in my clinic, the mold exposure ends, and the symptoms…
Jul 2, 2026 · 1:14:07
If you care about longevity, you have probably seen the same pattern over and over again. A new peptide, supplement, biological age test, off-label drug, or protocol starts…
Jun 30, 2026 · 41:31
A lot of women are taught to think about hormones only when something becomes impossible to ignore. Painful periods. Birth control decisions. Fertility anxiety. Postpartum…
Jun 25, 2026 · 57:01
When a couple is trying to get pregnant and it is not happening, the conversation can become very intense very quickly. Suddenly, you are hearing about IVF, egg freezing, AMH,…
Jun 23, 2026 · 52:35
Your body is constantly repairing, renewing, and rebuilding itself. Hundreds of millions of cells are replaced every few months, which sounds incredible until you ask the…
Jun 18, 2026 · 1:01:22
A lot of people are trying to do the right things. They are learning more, tracking their health, working on their stress, trying to be more present, and using the tools they…
Jun 16, 2026 · 59:35
When your body feels wired, depleted, foggy, inflamed, or slow to recover, the usual instinct is to add something else. Another supplement. Another device. Another protocol. But…
Jun 11, 2026 · 50:49
Modern life tells us that more freedom should make us happier. More independence, more control, more convenience, more space to do life on our own terms. But what if the thing we…
Jun 9, 2026 · 59:14
Sleep debt is usually treated like a personal problem. You sleep less, feel tired, and try to catch up later. But Dr. Kristen Holmes explains why that belief is too small. When…
Jun 4, 2026 · 57:11
Hormone symptoms are usually treated like a problem with levels. Progesterone is low. Estrogen is shifting. Cortisol is high. Testosterone is dropping. So the conversation often…
Jun 2, 2026 · 46:38
You can do the supplements, the IVs, the sauna, the clean eating, and the wellness routine, but if your body is still being exposed to toxins every day, you may be cleaning up a…
May 28, 2026 · 55:34
When we talk about health, longevity, and performance, the conversation often starts with the body. We look at biomarkers, sleep, nutrition, exercise, recovery, and protocols,…
May 26, 2026 · 55:59
Have you entered midlife and started gaining weight, feeling exhausted, waking up foggy, losing motivation, or noticing your mood shift while your labs keep coming back "normal"?…
May 21, 2026 · 57:06
If you think your skincare routine is protecting your skin, this conversation may make you look at your bathroom shelf differently. You've been taught to treat your skin like…
May 19, 2026 · 1:04:36
The gut and hormones have always been treated as two completely separate conversations in medicine, and that disconnect is quietly behind some of the most frustrating symptoms…
May 14, 2026 · 55:41
A lot of us are doing everything we can to stay healthy, taking supplements, wearing trackers, getting our labs done, and still ending up sick. And if you are like most people,…
May 12, 2026 · 1:00:18
Most high performing executives will spend thousands optimizing their glucose levels, their sleep, and their body composition without ever stopping to ask why none of it makes…
May 7, 2026 · 1:14:52
A lot of people are walking around exhausted, foggy, moody, and struggling with their cardiovascular health blaming stress, diet, age, and everything in between, never once…
May 5, 2026 · 47:02
Fatigue, brain fog, weight gain, hair loss, low libido, high cholesterol, and a doctor who keeps telling you your labs look normal. For the millions of people walking around with…
Apr 30, 2026 · 47:23
Biological aging is no longer just a concept tied to time. It is something we can now measure, track, and influence through data, lifestyle, and targeted interventions that…
Apr 28, 2026 · 58:31
Mitochondrial decline is one of the most overlooked drivers of aging, impacting energy, muscle function, cognitive performance, and immune resilience long before symptoms become…
Apr 23, 2026 · 1:01:54
Modern life is quietly accelerating biological aging, from posture and movement patterns to sleep disruption, chronic stress, and constant digital stimulation. Many of the…
Apr 21, 2026 · 1:03:53
Allergies, chronic inflammation, and constant exposure to environmental toxins are reshaping how our immune system functions, often in ways that go unnoticed until symptoms…
Apr 16, 2026 · 42:08
High-performing individuals often appear successful on the outside while quietly experiencing a loss of joy, emotional numbness, and chronic internal stress. This disconnect,…
Apr 14, 2026 · 55:24
Cognitive decline, mood disorders, and persistent neurological symptoms are often treated in isolation, even as underlying drivers like inflammation, infections, and blood flow…
Apr 9, 2026 · 55:54
Mental health conditions like depression, PTSD, and trauma related disorders remain difficult to treat, especially when underlying cognitive and emotional patterns persist over…
Apr 7, 2026 · 1:03:37
Depression, PTSD, and trauma related disorders continue to challenge modern medicine, even as our understanding of the brain and consciousness rapidly evolves. New research…
Apr 2, 2026 · 1:17:45
Cholesterol remains one of the most debated biomarkers in cardiovascular medicine, yet many people still misunderstand what it actually tells us about metabolic health and…
Mar 31, 2026 · 45:13
Chronic stress, cognitive overload, and neurodegenerative disease are rising as modern life pushes the brain beyond what it was designed to handle. At the same time, most people…
Mar 26, 2026 · 1:41:17
Chronic inflammation, environmental toxins, and metabolic dysfunction continue to accelerate aging and chronic disease across modern populations. Many of the biggest drivers of…
Mar 24, 2026 · 45:08
Chronic symptoms often get labeled, managed, and medicated, yet the root cause can remain hidden. Parasites, mold exposure, Lyme disease, and microbial imbalances may quietly…
Mar 19, 2026 · 1:00:46
Strength is the foundation of longevity. When muscle, cardiovascular fitness, mobility, balance, sleep, and nutrition align, performance improves, metabolism sharpens, and aging…
Mar 17, 2026 · 56:41
Most people think medicine is about treating disease. What if the real future of healthcare is preventing illness and optimizing human potential long before symptoms appear. In…
Mar 12, 2026 · 1:07:47
Raising healthy children today requires more discernment than ever. Between conflicting vaccine guidance, ultra processed food marketing, and the explosion of screen exposure,…
Mar 10, 2026 · 1:32:11
Chronic stress is quietly reshaping how we think, perform, sleep, and recover. In a world optimized for productivity, we rarely prioritize the one variable that determines long…
Mar 5, 2026 · 58:57
Fertility is declining while menopausal symptoms are appearing earlier. Metabolic dysfunction, chronic stress, and environmental exposures are reshaping reproductive health for…
Mar 3, 2026 · 51:14
Teen mental health is deteriorating in real time, fueled by ultra processed food, chronic stress, and constant screen exposure. The earlier we intervene, the more resilient the…
Feb 26, 2026 · 1:18:08
Most conversations about brain health focus on intelligence or genetics. True cognitive performance depends on how the brain is trained, supported, and allowed to recover across…
Feb 24, 2026 · 1:08:45
Most women are taught to accept fatigue, weight gain, brain fog, and mood changes as a normal part of aging. What if the real issue has been overlooked gut health, muscle loss,…
Feb 19, 2026 · 1:27:51
Most women are taught that aging means decline, less energy, less strength, and less desire. What if the real problem has never been age itself, but untreated hormone loss and…
Feb 17, 2026 · 1:24:12
Most people are told to lose weight to get healthy. What if that mindset is the reason metabolic health keeps getting worse, muscle keeps disappearing, and fat loss never lasts.…
Feb 12, 2026 · 1:06:49
Most people assume viral health advice is backed by solid science. What if much of it is built on cherry-picked studies, misleading mechanisms, and narratives designed to sell…
Feb 10, 2026 · 46:26
Most people assume mold exposure causes allergies or respiratory issues. What if it is actually driving chronic inflammation, hormone disruption, and neurological symptoms that…
Feb 5, 2026 · 1:08:53
Most people think brain aging is inevitable. What if the real future of longevity is protecting cellular health long before symptoms appear. In this episode of Extend, we sit…
Feb 3, 2026 · 1:08:05
Most people know what they should do to be healthy, yet still struggle to follow through. What if the real barrier is not discipline or knowledge, but mindset. In this episode of…
Jan 29, 2026 · 51:02
Most people assume losing strength, energy, and bone health is inevitable as we age. But what if maintaining muscle, optimizing hormones, and protecting bone density were about…
Jan 27, 2026 · 1:02:18
Most people focus on cholesterol and plaque when thinking about heart health. The truth is, there are hidden drivers that can silently damage your arteries and increase…
Jan 22, 2026 · 49:58
Most people assume fatigue, low energy, and age-related decline are unavoidable. What if supporting your body, optimizing recovery, and enhancing longevity were about activating…
Jan 20, 2026 · 1:04:27
Most people assume joint pain, fatigue, and limited mobility are inevitable with age. But what if protecting your joints, optimizing recovery, and maintaining energy were about…
Jan 15, 2026 · 25:39
How much control do you really have over your alcohol consumption and its effects on your health? Many people assume drinking is just part of social life, but science shows there…
Jan 13, 2026 · 1:01:48
Most people think weight loss is about discipline, calories, or finding the right medication. But what if the real issue is that we've misunderstood how hormones, digestion, and…
Jan 8, 2026 · 20:45
How much control do you actually have over the toxins in your daily environment? Most people assume chemical exposure is unavoidable, but the science shows there are practical…
Jan 6, 2026 · 1:12:48
Toxin exposure rarely announces itself loudly, yet it quietly shapes hormone balance, immune resilience, mood, and neurological health long before a diagnosis appears. The real…
Jan 1, 2026 · 28:42
Most people think they're doing "enough" for their health, yet nearly 90% of Americans are metabolically unhealthy and don't know it. In this episode, I challenge outdated…
Dec 30, 2025 · 46:06
Mental health is shaped by how well the brain produces energy, how well the nervous system remains under stress, and how effectively the mind adapts over time. When these systems…
Dec 25, 2025 · 31:01
Over the past year on Extend, I've had powerful conversations with experts who all kept pointing back to the same foundation: strength training. So in this episode, I'm bringing…
Dec 23, 2025 · 23:36
Metabolic health is the foundation that determines how your body produces energy, manages inflammation, regulates hormones, and protects you from chronic disease. When it breaks…
Dec 18, 2025 · 1:18:53
What if the stress you feel every day is not a personal failure, but a biological response to how modern life pulls at your nervous system? In this episode, I sit down with Dr.…
Dec 16, 2025 · 36:16
How much control do you actually have over how your brain ages? Most people assume memory loss and cognitive decline are inevitable, but the science tells a very different story.…
Dec 11, 2025 · 45:55
Have you ever wondered why you can be "doing everything right" with your health and still feel inflamed, foggy, or depleted? The more I study longevity, the more I am convinced…
Dec 9, 2025 · 1:00:40
Most people still think GLP-1s are "weight loss shots," but what we are really doing is changing biology at the level of appetite and inflammation, with ripple effects across…
Dec 4, 2025 · 54:37
Most people think heart disease is obvious and predictable, yet women often present with completely different warning signs that traditional testing fails to catch. We now have…
Dec 2, 2025 · 1:11:13
Most people think about the gut as a digestive system, yet emerging research shows it functions more like a command center shaping immunity, metabolism, mood, and even coronary…
Nov 27, 2025 · 47:40
Most people hear "saturated fat" and think of something harmful, yet emerging research reveals that one specific fatty acid supports stronger cell membranes, healthier metabolic…
Nov 25, 2025 · 1:06:17
Most of us think inflammation is something we can fix with supplements, lab tests, or the latest diet trend. But what if the real solution comes from ancient wisdom that modern…
Nov 20, 2025 · 44:50
Most of us grew up thinking anything sold at the grocery store was safe to eat. But behind every "heart healthy," "high protein," or "low fat" label lies a different truth one…
Nov 18, 2025 · 1:12:09
You can eat healthy, exercise daily, and still struggle with fatigue, inflammation, or brain fog. Why? Because every system in your body is connected. The gut, brain, and immune…
Nov 13, 2025 · 1:29:14
What if the future of medicine isn't about diagnosing disease, but preventing it entirely? For decades, our healthcare system has only reacted once things go wrong. We measure…
Nov 11, 2025 · 1:14:50
What if the real key to longevity has nothing to do with your workouts or supplements, but with how well your brain is wired to adapt, repair, and thrive? In this episode of…
Nov 6, 2025 · 1:30:36
What if the key to living longer and feeling younger has been hidden in ancient medicine all along? Long before supplements, peptides, or wearables, healing was about restoring…
Nov 4, 2025 · 40:08
What if the real secret to longevity isn't found in science alone, but in how we choose to live, love, and connect every day? In this special posthumous episode of EXTEND, I…
Oct 30, 2025 · 44:48
What if the real turning point for women's health isn't menopause itself, but the decade before it? Long before the symptoms hit, your brain, bones, and heart are already…
Oct 28, 2025 · 45:27
You can eat clean, track your labs, take supplements, and still feel anxious, inflamed, tired, or flat. Why? Because the gut, brain, immune system, and hormones are in constant…
Oct 23, 2025 · 1:15:07
You have brain fog. You're gaining weight faster and losing it slower. You think it's stress, aging, or just life… But what if it's your liver screaming for help? In this episode…
Oct 21, 2025 · 1:17:53
We track our sleep, count our macros, optimize every supplement, yet most people's bodies are still stuck in survival mode. What if true longevity starts not with another…
Oct 16, 2025 · 1:40:40
What if your immune system could actually age backwards? For decades, we've accepted that inflammation, fatigue, and slower recovery are inevitable with age, but new research…
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