Burn Fat, Keep Muscle: Inside the Science of the Protein-Sparing Modified Fast — Optimal Protein Podcast with Vanessa Spina

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In this solo episode, Vanessa Spina breaks down the science and strategy behind one of the most effective tools for rapid fat loss and muscle preservation — the Protein-Sparing Modified Fast (PSMF).

Following her in-depth interview with Dr. David Jockers, Vanessa explains exactly how this approach works, why it's so powerful for resetting metabolism, and how to implement it safely for optimal results.

If you've ever wondered how to burn fat quickly without losing muscle, how to overcome plateaus, or how to use short, strategic fasting phases for body recomposition, this episode is your ultimate guide.

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💪 Key Takeaways

You can burn fat without losing muscle by keeping protein high and calories low.
Autophagy occurs from calorie restriction — not protein restriction.
Ketones created during PSMF provide mental clarity, calm, and focus.
Strategic refeeds help lock in fat loss and prevent rebound weight gain.
When combined with strength training, PSMF becomes a powerful metabolic reset tool.

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Mentioned in This Episode

Effect of fasting-mimicking diets with low and high protein content on cardiometabolic health and autophagy (Burns et al., 2024)
Dr. Eric Helms & Dr. Martin Rufalo meta-analysis on protein intake during energy restriction
Dr. David Jockers, The Dr. Jockers Functional Nutrition Podcast
Historical PSMF research by Dr. George Blackburn

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👤 Connect with Vanessa:

• Instagram: @ketogenicgirl

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🎙 The content in this podcast is for informational purposes only and not nutritional or medical advice. Always consult your healthcare provider before making major dietary or lifestyle changes.