272 Slowing Biological Aging Naturally: Autophagy, Diet and Longevity with Leslie Kenny

What if one of the most powerful anti-aging tools already exists within your body? This episode explores autophagy, the body's natural cellular renewal system, and how activating it can support healthy aging and longevity. Longevity expert Leslie Kenny shares her personal journey of reversing autoimmune disease and translating cutting-edge science into practical strategies. Listeners will discover how autophagy promoting spermidine, proper nutrition, and baseline lifestyle habits influence cellular repair, resilience, and biological aging.   
L eslie Kenny is the founder of Oxford  Healthspan , a company focused on translating longevity science into practical health solutions.  She is a longevity researcher with expertise in cellular aging, autophagy, and immune system modulation.  Her career includes work in finance and policy before a personal medical crisis led her to  transition into health science.  She specializes in spermidine research and its role in activating autophagy and influencing the hallmarks of aging.  She is co-founder of the Oxford Longevity Project, a nonprofit dedicated to education in healthy aging.  

Episode Timeline  

00:00 – Welcome and introduction  

02:00 – Reframing aging as a modifiable biological process  

03:50 – Leslie Kenny's autoimmune diagnosis and turning point  

10:50 – Limitations of modern healthcare and the need for prevention  

14:50 – What autophagy is and why it matters for longevity  

17:00 – Spermidine and its role in cellular renewal pathways  

21:30 – Nutrition, mushrooms, and dietary sources of spermidine  

24:30 – Hallmarks of aging and systemic cellular decline  

31:00 – Development of  Primadine  and supplement formulation science  

37:00 – Practical strategies: fasting, diet, and supplementation  

41:30 – Key takeaways on influencing biological  agin  

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