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The death of both Alexander Balas and Ptolemy VI in 145 meant that the throne belonged to Demetrius II Nicator. Yet another round of civil war would soon follow Demetrius' increasingly unpopular reign, as the official Diodotus Tryphon would endorse the infant Antiochus VI Dionysius as king, before proclaiming himself one too. The Hasmoneans in Judea hoped to leverage the situation to their advantage until the death of Jonathan Apphus, who was replaced by his brother Simon Thassi as High Priest. Such instability in Syria allowed the Parthian ruler Mithridates I to conquer Babylonia in 141, forcing Demetrius to make a desperate attempt to reclaim the Upper Satrapies before his empire crumbled around him.
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